V. Palchykov, A. Gaponov
2020
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Abstract
Abstract The discovery of new effective catalytic methods for the synthesis of 1,3-amino alcohols, as well as the development of novel transformations of these compounds, has been an extremely active area of research in recent years. As we demonstrate in this chapter, in just one or two steps 1,3-amino alcohols and their phenol analogs can be converted into a vast array of four-to-eight-membered rings of great biological importance. The diversity of possible transformations has resulted in a torrent of publications on this topic. This review covers recent (2007 to early 2019) literature on transformations of 1,3-amino alcohols leading to diverse families of N,O,S-heterocycles, including azetidines, pyrrolidines, indoles, 1,3-oxazinanes, 1,3-oxazines, 1,3-oxazinane-2-ones, pyridines, quinolines, quinazolines, 1,4-oxazepanes, 1,4-diazepanes, benzo[f][1,4]oxazepines, and benzo[e][1,4]diazepines. The review aims to give the readers an insight into the great synthetic utility of 1,3-amino alcohols and related compounds. It presents the most modern methods for their expedited conversion into a broad range of biologically relevant heterocycles.