A. Armitage, K. Wooldridge
Dec 24, 1960
Citations
0
Influential Citations
3
Citations
Journal
Nature
Abstract
1,3-DIMETHYLXANTHINE (theophylline) is readily converted into the corresponding 6-thio derivative by treatment with phosphorus pentasulphide in pyridine. The choline salt (M. and B. 4926A) of this derivative is more active than choline theophyllinate in relaxing the bronchial muscle (guinea pig tracheal ring preparation) and in dilating the coronary vessels (dog heart-lung preparation). This result led us to prepare and examine a series of homologous compounds, the most active in these two respects being 3-isobutyl-1-methyl-6-thioxanthine (M. and B. 5924).