Raymond C. F. Jones, Kathryn A. M. Duller, S. Vulto
1998
Citations
0
Influential Citations
10
Citations
Journal
Journal of The Chemical Society-perkin Transactions 1
Abstract
1,3-Dipolar cycloadditon of nitrile oxides, formed in situ by dehydration of primary nitro compounds, with pyrrolidine enamines of protected γ-hydroxy-β-keto esters affords isoxazole-4-carboxylates; these are subjected to N–O bond cleavage and lactonisation to afford 3-acyltetronic acids and 3-acyl-4-hydroxytetrahydropyran-2-ones.