L. Sternbach
1971
Citations
1
Influential Citations
120
Citations
Quality indicators
Journal
Angewandte Chemie
Abstract
Numerous clinically used compounds having favorable tranquilizing and toxic properties possess the 1,4-benzodiazepine skeleton. This group of active substances is readily accessible, e.g. by ring enlargement of quinazoline derivatives, by ring contraction of benzoxadiazocines, and by synthesis from aminobenzophenones, constructing the seven-membered ring in many cases in one step. The relationships between type and position of substituents and the pharmacological properties are illustrated using 1,3-dihydro-5-phenyl-1,4-benzodiazepin-2-ones as examples.