C. Foged, L. Hansen, C. Halldin
Aug 1, 1993
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Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
A 14C labelled form of (+)-8-chloro-5-(2,3-dihydrobenzofuran-7-yl)-7-hydroxy-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine (NNC 756) (8) was synthesized in 7 steps, including resolvation of the active (+)-form, starting from [14C]methyl iodide and 7-benzofurancarbaldehyde. The overall radiochemical yield was 11%. The radiochemical purity of [4-14C]NNC 756 was higher than 98% with a specific radioactivity of 24 mCi/mmol.