E. M. Holt, G. Caignan
Feb 1, 2000
Citations
0
Influential Citations
8
Citations
Journal
Zeitschrift für Kristallographie - Crystalline Materials
Abstract
4-(2-Pyrrolyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-bis(methoxycarbonyl), 4-(3-furyl)-2,6-dimethyl-1,4-di-hydropyridine-3,5-bis(methoxycarbonyl) and 4-(3-bromo-2-furyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-bis(methoxy-carbonyl) are potential antiarrhythmic pharmaceuticals with Ca2+ antagonistic activity in L type voltage gated channels. Conformation of the 3 and 5 substituted carbonyl groups appears influenced by hydrogen bonding with ap orientation observed for carbonyl groups serving as H-bonding acceptor groups in the solid. This behavior appears to mimic in vivo conformational preferences.