W. Fung, S. Karim, C. Tye
Jul 6, 1974
Citations
0
Influential Citations
81
Citations
Quality indicators
Journal
Lancet
Abstract
Abstract 15(R)15 Methylprostaglandin E 2 methyl ester has been given orally in doses of 150 μg. 6-hourly to 10 Chinese subjects with proven gastric ulcer for 2 weeks. The control group consisted of 9 Chinese subjects with proven gastric ulcer without prostaglandin treatment. All were inpatients and were prescribed bed rest. Gastric-ulcer healing was assessed endoscopically with a duodenofiberscope. Endoscopic visualisation of the ulcer and colour photography of the ulcer crater were undertaken just before and 2 weeks after treatment. In the prostaglandin group complete healing was seen in 3 cases, considerable healing in 6 cases, and slight healing in 1 case. In the control group complete healing was seen in none, considerable healing in 2 cases, slight healing in 4 cases, and no healing in 3 cases. This difference was highly significant. There was no significant difference between the two groups in the severity of ulcer or in age and sex distribution. 15(R)15 Methyl P.G.E 2 methyl ester is highly effective in promoting the healing of gastric ulcers in Chinese subjects.