P. Druzgala, N. Bodor
Apr 1, 1990
Citations
0
Influential Citations
7
Citations
Journal
Synthetic Communications
Abstract
Abstract 11β,17α-Dihydroxy-3-oxoandrost-4-ene 17β-carboxylic acid (cortienic acid), or its methyl ester, are efficiently and selectively alkylated at the 17α-position using methyl iodide in a solid-liquid biphasic system consisting of potassium hydroxide and dimethyl sulfoxide. When a higher alkyl halide homolog is used, it is necessary to protect the α-enone function.