R. Elton, Ehard F. Nutting
Aug 1, 1961
Citations
0
Influential Citations
10
Citations
Journal
Proceedings of the Society for Experimental Biology and Medicine
Abstract
Summary 17α-Ethynyl-4-estrene-3,17-diol diacetate is an agent that exerts unique hormonal effects. By the subcutaneous route EED is 1 to 2 times more potent than progesterone in producing proliferation of the uterine epithelium in rabbits, yet it is also capable of inhibiting this progestational response. Buccally, EED is approximately 40 times more effective than progesterone, administered by the same route. EED is estrogenic as measured in both the mouse uterine growth assay and the rat vaginal smear assay yet when administered in conjunction with estrone EED acts as an estrogen-antagonist. These opposing activities can best be explained by the differences in hormonal dominance at low and high dose levels. We express thanks to Mrs. Juliette Sleeper, Mrs. Kathryn Paulsen and Miss Diane Richter for technical assistance during these studies.