M. Numazawa, A. Mutsumi, K. Hoshi
May 15, 1989
Citations
0
Influential Citations
28
Citations
Journal
Biochemical and biophysical research communications
Abstract
3-Deoxy steroids having a 4-ene system were found to be competitive inhibitors of human placental aromatase. 19-Hydroxy-4-androsten-17-one (2) potently inhibits the enzyme with an apparent Ki of 12.5 nM, but does not produce a time-dependent inactivation of the enzyme.