R. Lin, P. Connolly, Shenlin Huang
Jun 3, 2005
Citations
3
Influential Citations
114
Citations
Quality indicators
Journal
Journal of medicinal chemistry
Abstract
A series of 1-acyl-1H-[1,2,4]triazole-3,5-diamine analogues were synthesized as cyclin-dependent kinase (CDK) inhibitors. These compounds showed potent and selective CDK1 and CDK2 inhibitory activities and inhibited in vitro cellular proliferation in various human tumor cells. Representative compound 3b demonstrated in vivo efficacy in a human melanoma A375 xenograft model in nude mice.