Pavel K. Mykhailiuk, V. Starova, Vladimir Iurchenko
May 20, 2013
Citations
0
Influential Citations
8
Citations
Journal
Tetrahedron
Abstract
Abstract 1-Amino-4,4-difluorocyclohexanecarboxylic acid has been designed as a fluorinated analogue of the pharmacologically relevant 1-aminocyclohexanecarboxylic acid. The synthesis has been performed in three steps from a commercially available material in 22% overall yield. An impact of fluorine atoms on conformation, lipophilicity, acidity and fluorescent properties of the amino acid has been studied. Various practical applications of the obtained compound are suggested.