H. A. A. El-Nabi
2002
Citations
0
Influential Citations
12
Citations
Journal
Tetrahedron
Abstract
Abstract 3-Di(methylsulfonyl)methylene-pyrrol-2-one and 2-(1-aryl-5-methoxy-2-oxo-2,3-dihydro-1 H -3-pyrrolylidene)malononitrile were obtained from 1-aryl-5-methoxypyrrolones. Aziridine and hydroxylamine reacted with pyrrol-2-one to afford 2,7-diazaspiro[4.4]nona-3,6-diene and oxime derivatives, respectively. Pyrrolo[2,3- c ]isoxazoles or pyrrolo[2,3- c ]isothiazole were formed in high yield from oximes depending upon the reaction conditions employed for ring closure. Treatment of pyrrolylidene malononitrile with N 1 , N 2 -di(4-chlorophenyl)acetamidine in ethyl acetate furnished azepine derivatives in 70–75% yield.