O. Peeters, D. Jamróz, N. Blaton
Dec 15, 1998
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Journal
Acta Crystallographica Section C-crystal Structure Communications
Abstract
The single-crystal X-ray structures of (+)-1-{(2R)-1-[(3,4-dichlorophenyl)acetyl]piperidin-2-ylmethyl}-pyrrolidinium chloride monohydrate (C 18 H 25 Cl 2 N 2 O + .Cl - .H 2 O; BRL-52536A) and (-)-1-((25)-1-[(3,4-dichlorophenyl)acetyl]piperidin-2-ylmethyl}piperidinium chloride (C 19 H 27 Cl 2 N 2 O + .Cl - ; BRL-52781A) have been determined. BRL-52536A is the inactive stereoisomer of BRL-52537A, the highly selective and potent lead compound of the series. The pharmacophore N-C-C-N sp 2 torsion angle is (+)-synclinal in the 2S configuration.