R. Misra, David B Rawlins, Hai-yun Xiao
Mar 24, 2003
Citations
1
Influential Citations
52
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
1H-Pyrazolo[3,4-b]pyridine 3 (SQ-67563) has been shown to be a potent, selective inhibitor of CDK1/CDK2 in vitro. In cells 3 acts as a cytotoxic agent with the ability to block cell cycle progression and/or induce apoptosis. The solid state structure of 3 bound to CDK2 shows 3 resides coincident with the ATP purine binding site and forms important H-bonding interactions with Leu83 on the protein backbone.