Shengqing Ye, Huanhuan Wang, Jie Wu
Mar 14, 2011
Citations
0
Influential Citations
38
Citations
Journal
ACS combinatorial science
Abstract
A novel and highly efficient three-component reaction of 2-alkynylbenzaldoxime, carbodiimide, with electrophile (bromine or iodine monochloride) is disclosed, which generates 1-(4-haloisoquinolin-1-yl)ureas in good yields under mild conditions. Subsequent palladium-catalyzed Suzuki-Miyaura coupling reaction is introduced, leading to the diverse 1-(isoquinolin-1-yl)ureas.