Xiao-kui Wang, Guo-ming Zhao, Yao Chen
Feb 1, 2009
Citations
0
Influential Citations
12
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
A new series 1-oxo-3-substitute-isothiochroman-4-carboxylic acid compounds have been designed and synthesized. Screening of these molecules for FAS inhibition in vitro has indicated that compounds 2c and 2d showed more effective FAS inhibition activities and higher therapeutic index than C75.