Ian T Huscroft, Emma J Carlson, Gary G Chicchi
2006
Citations
0
Influential Citations
15
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
1-Phenyl-8-azabicyclo[3.2.1]octane ethers are NK(1) receptor antagonists. Substitution at the 6-exo-position led to high affinity NK(1) antagonists with a prolonged duration of action in vivo. Incorporation of an alpha-methyl substituent in the pendent benzyl ether side chain gave compounds with increased selectivity over the hERG channel.