Roberto Frutos-Pedreño, J. García‐López
Aug 18, 2016
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Influential Citations
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Journal
Advanced Synthesis & Catalysis
Abstract
The synthesis of biologically relevant homophthalimide and 3-aminoisocoumarin nuclei via palladium-catalyzed carbonylation of 2-(2-iodoaryl)acetamides has been developed. The degree of N-substitution on the starting amide substrate dictates whether C−N or C−O coupling takes place in the final step of the catalytic cycle giving rise to each type of heterocycle. The introduction of a second C−halogen bond in the starting acetamides allows a catalytic cascade double carbonylation involving a C−H activation step to give fused heterocyclic structures.