I. Ukrainets, L. A. Petrushova, S. Shishkina
Jan 30, 2015
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Influential Citations
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Journal
Chemistry of Heterocyclic Compounds
Abstract
The alkylation of methyl 4-hydroxy-1-methyl-2,2-dioxo-1Н-2λ6,1-benzothiazine-3-carboxylate in DMSO or acetone with ethyl iodide at 25°С gave a mixture of 3-ethyl- and 4-ethoxy-substituted derivatives, in complete agreement with quantum-chemical calculations. The ratio of С- and О-alkylation products changed depending on the alkali metal carbonate used as a base. The reaction practically did not proceed in anhydrous THF or water due to the low nucleophilicity of the anion.