K. Uneyama, K. Sugimoto, O. Morimoto
Sep 1, 1991
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Journal
Journal of Fluorine Chemistry
Abstract
Abstract 2,2,2-Trifluoroacetimidoyl chlorides 1 are much more stable than the corresponding nonfluorinated chlorides because of the deactivation for hydrolysis by the strong electron-withdrawing fluorine atom and thus useful as synthetic blocks. They react smoothly with nucleophilics such as Grignard reagents, active methylene compounds, and primary amines. 2,2,2-Trifluoroacetamidines 2 are promising precursors for CF 3 -containing heterocycles as shown in the scheme. Preparations and reactions of 2 are discussed in details.