Andrey V. Bogolubsky, Yurii S. Moroz, Pavel K. Mykhailiuk
Sep 14, 2015
Citations
0
Influential Citations
8
Citations
Journal
ACS combinatorial science
Abstract
A one-pot parallel synthesis of N(1)-aryl-N(2)-alkyl-substituted oxamides with 2,2,2-trifluoroethyl chlorooxoacetate was developed. The synthesis of a library of 45 oxamides revealed higher efficiency of this reagent over the known ethyl chlorooxoacetate. The reagent was successfully used to prepare the known oxamide-containing HIV entry inhibitors.