Gergely L. Tolnai, A.Pálné Székely, Zita Makó
Feb 26, 2015
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Influential Citations
41
Citations
Journal
Chemical communications
Abstract
A novel highly C3 selective metal free trifluoroethylation of indoles using 2,2,2-trifuoroethyl(mesityl)-iodonium triflate was developed. The methodology enables the introduction of a trifluoroethyl group in a fast and efficient reaction under mild conditions with high functional group tolerance. Beyond the synthetic developments, quantum chemical calculations provide a deeper understanding of the transformation.