Dehua Huang, Steve F. Poon, D. Chapman
Nov 15, 2004
Citations
0
Influential Citations
30
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
Structure-activity relationship studies on 3-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitrile 2 led to the discovery of 2-(2-[3-(pyridin-3-yloxy)phenyl]-2H-tetrazol-5-yl)pyridine (10)-a highly potent and selective mGlu5 receptor antagonist with good brain penetration and in vivo receptor occupancy in rat and cross-species oral bioavailability.