Yangyang Liu, Deli Chen, Zhangxin Yu
Dec 22, 2018
Citations
0
Influential Citations
14
Citations
Quality indicators
Journal
Natural Product Research
Abstract
Abstract Two new chromone derivatives, 7-hydroxy-2-[2-(3'-methoxy-4'-hydroxyphenyl)-ethyl]chromone (1), and 6,7-dimethoxy-2-[2-(3'-hydroxyphenyl)-ethyl]chromone (2) were isolated from the EtOH extract of agarwood of Aquilaria sinensis, together with eleven known analogues. Their structures were established by detailed HR-ESIMS, 1D and 2D NMR spectroscopic analysis, as well as comparison with the literature data. Selected the isolates (1, 2, 4–8, 10, 11) were tested for their antitumor activities against SMMC-7721, MGC-803 and OV-90 cell lines using the MTT method with cisplatin and paclitaxel as the positive control. All the tested compounds showed weak cytotoxic activities with IC50 values ranged from 18.82 to 37.95 µg/ml. GRAPHICAL ABSTRACT