Xiong Zhu, Yue Wang, T. Lu
Oct 3, 2009
Citations
1
Influential Citations
8
Citations
Journal
Acta Crystallographica Section E: Structure Reports Online
Abstract
In the title compound, C16H16N2O3S·C5H5N, the benzene and thiazole rings of the Febuxostat [2-(3-cyano-4-isobutyloxy)phenyl-4-methyl-5-thiazolecarboxylic acid] molecule are almost coplanar [dihedral angle = 2.4 (1)°]. The carboxyl group is coplanar with the thiazole ring [O—C—C—C and O—C—C—S torsion angles of −0.7 (4) and 0.6 (3)°, respectively]. The pyridine molecule of crystallization is linked to the Febuxostat molecule through an O—H⋯N hydrogen bond. A weak π–π stacking interaction is observed between the benzene ring of the Febuxostat molecule and pyridine molecule, with a centroid–centroid distance of 3.7530 (18) Å.