E. Hamilton, E. Bywaters
Mar 1, 1960
Citations
0
Influential Citations
5
Citations
Journal
Annals of the Rheumatic Diseases
Abstract
Clarke, Clarke, and Mosher (1958) have recently reported on the therapeutic action of 2,3,6and 2,4,6-trihydroxybenzoic acid (THB) in twelve patients with rheumatic fever and eleven others. The latter compound, usually in a dosage of 1 to 1 33 g./24 hrs, was believed to have a clinical antirheumatic potency six to eight times that of salicylic acid and no toxicity. We have found it to have no anti-rheumatic potency in classical rheumatic fever, judged by pain and temperature response in three patients receiving doses varying from 1 to 8 g./24 hrs, whereas calcium aspirin (Disprin) in a dosage of about 4 g./24 hrs was dramatically effective in the same three patients (Figure).