Chun-ping Dong, Akinori Uematsu, S. Kumazawa
Aug 21, 2019
Citations
0
Influential Citations
11
Citations
Journal
The Journal of organic chemistry
Abstract
Metal-free, oxidative four-component Ugi reactions (U-4CRs) were conducted to synthesize di-peptides from two different amines, isocyanides, and carboxylic acids using 2,4,6-trihydroxybenzoic acid catalyst in O2 atmosphere. The organocatalytic U-4CRs proceed via oxidative cross-coupling of benzylamines with other aliphatic or aromatic amines to form imines, followed by condensation with isocyanides and carboxylic acids. The U-4CRs via cross-coupling of amines are rare, and the simple, metal-free procedures are advantageous for further applications in drug and heterocycle syntheses.