M. Nishimura, Y. Hori, S. Nishiyama
1993
Citations
0
Influential Citations
27
Citations
Quality indicators
Journal
European Journal of Dermatology
Abstract
The use of 1α, 24 (R)-dihydroxyvitamin D3 (1α, 24R (OH) 2 D 3 ), a structural analogue of naturally occurring, active vitamin D 3 (1α, 25 (OH) D 3 ), in the treatment of psoriasis is reviewed based on the results of basic biological investigations and clinical studies which were previously described in the literature. Compared with topical corticosteroids, topical 1α, 24R (OH) 2 D 3 has been proven to be equally effective. Direct comparative studies on the antipsoriatic effect of 1α, 24R (OH) 2 D 3 with those of 1α, 25 (OH) 2 D 3 and calcipotriol (MC 903), another analogue, have not been done yet. The hypercalcemic activity of 1α, 24R (OH) 2 D 3 is weaker than that of 1α, 25 (OH) 2 D 3 . 1α, 24R (OH) 2 D 3 is applicable to the lesions on the face, where irritant dermatitis may occur by the application of MC 903