J. Choi, Younjoo J. Lee, Eunmyoung Kim
Feb 17, 2003
Citations
0
Influential Citations
8
Citations
Journal
Tetrahedron Letters
Abstract
The development of the 2-(4-trifluoromethylphenylsulfonyl)ethoxycarbonyl (Tsc) function, a novel base-sensitive amino-protecting group, and its application to the preparation of DNA-binding polyamides are described. Pyrrole–imidazole polyamides were synthesized by an efficient solid-phase method under conditions compatible with Fmoc chemistry using two Tsc-protected amino acids, Tsc-Py-OH 1a and Tsc-Im-OH 1b.