A. L. Davis, R. Lloyd, S. Maul
Feb 1, 1964
Citations
0
Influential Citations
8
Citations
Journal
Archives of biochemistry and biophysics
Abstract
The reaction of 1,4-dichloro-2-butyne with potassium phthalimide yielded N -(4-chloro-2-butynyl)phthalimide, which was subsequently condensed with ethyl acetamidomalonate. Acid hydrolysis of the condensation product gave 2,6-diamino-4-hexynoic acid. Growth inhibition of Leuconostoc dextranicum 8086 by 2,6-diamino-4-hexynoic acid is reversed in a competitive manner by lysine over a hundredfold range of increasing concentrations with an inhibition index of about 10.