J. Kerrigan, Jennifer J. Shirley
Feb 20, 1996
Citations
0
Influential Citations
7
Citations
Journal
Bioorganic & Medicinal Chemistry Letters
Abstract
Abstract Derivatives of 2-[(alkylsulfonyl)oxy]-1H-isoindole-1,3(2H)-diones (N-(sulfonyloxy)phthalimides) with ring substituents in the 6-position were found to exhibit enhanced inhibitory potency and selectivity for HLE. The most potent inhibitor of HLE in this series was 6-amino-2-[(methylsulfonyl)oxy]-1H-isoindole-1,3(2H)-dione10 with a k obs [I] of 110,000 M−1 s−1.