S. Rogers, R. W. Huigens, C. Melander
Jul 2, 2009
Citations
3
Influential Citations
76
Citations
Quality indicators
Journal
Journal of the American Chemical Society
Abstract
A number of 2-aminobenzimidazole derivatives were synthesized and screened for their ability to inhibit and disperse bacterial biofilms. From these compounds, a lead 2-aminobenzimidazole was identified that both inhibited and dispersed MRSA, vancomycin-resistant Enterococcus faecium, and Staphylococcus epidermidis biofilms. Mechanistic studies showed that the activity is Zn(II)-dependent, potentially via a direct zinc-chelating mechanism.