Jian Jin, Yonghui Wang, Feng Wang
May 1, 2008
Citations
0
Influential Citations
13
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
A series of 2-aminomethyl piperidines has been discovered as novel urotensin-II receptor antagonists. The synthesis, initial structure-activity relationships, and optimization of the initial hit that resulted in the identification of potent, cross-species active, and functional urotensin-II receptor antagonists such as 1a and 11a are described.