S. Cacchi*, G. Fabrizi, Luca M. Parisi
Feb 1, 2004
Citations
0
Influential Citations
23
Citations
Journal
Synlett
Abstract
2-Aryl and 2-heteroaryl pyrrolo[2,3-b]quinoxalines have been prepared in good to high yield through the reaction of 1-alkynes with 2-bromo-3-trifluoroacetamidoquinoxaline in the presence of catalytic amounts of CuI, PPh 3 , and K 2 CO 3 in dioxane at 110 °C. The reaction appears to tolerate a wide range of functionalized 1-alkynes, including those containing ether, alcohol, amide, aldehyde, ketone, ester, and nitro groups.