Michael O'donnell, J. Charrier
Apr 27, 2016
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Citations
Journal
Tetrahedron Letters
Abstract
Abstract A novel synthetic route to 2,4-functionalized pyrimidines is reported. The approach uses 2-chloro-4-tetrafluorophenoxypyrimidine, that enables sequential palladium catalyzed functionalization at the pyrimidine C-2 position, followed by S N Ar displacement with diverse amines at C-4 . The broad utility of this ‘ C-2 then C-4 ’ functionalization sequence has been demonstrated with a range of cross-coupling partners and amines.