Yong-Dae Park, Jeum‐Jong Kim, Sungmin Cho
May 2, 2005
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0
Influential Citations
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Journal
Synthesis
Abstract
2,4,5-Trichloro- (2a) and 2,4-dichloro-5-methoxypyridazin-3(2H)-one (2b) are novel electrophilic chlorinating agents. α-Chlorination of active methylene/methine compounds with 2 in the presence of either Lewis or protonicacids in dichloromethane (for Lewis acid) or water (for protonic acid or none) at room temperature gave also selectively α-monochlorides and/or a,a-dichlorides in good to excellent yields.