J. Skoda, Z. Flegelová, J. Farkaš
Jan 4, 1973
Citations
0
Influential Citations
11
Citations
Journal
Biochemical and biophysical research communications
Abstract
Abstract 2H-1,3-Oxazine-2,6(3H)-dione inhibits the growth of Escherichia coli B, the inhibition being complete at a concentration of 10−4M. It may be relieved with uridine, cytidine and partly with uracil. Orotic acid, cytosine, purine bases and purine ribonucleosides show no effect. At a molar ratio of uridine to the inhibitor of 1:2 the inhibition is completely suppressed. 2H-1,3-Oxazine-2,6(3H)-dione is thus a novel inhibitor of the biosynthesis of pyrimidine precursors of nucleic acids.