Ou Xiu-li
2010
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Journal
Strait Pharmaceutical Journal
Abstract
OBJECTIVE Discussion from raw materials into benzyl and lactic acid reactiOn,In under the action of R-Ni,the optimum reaction conditions for 2-hydroxy-4-phenylbutanoic acid.METHODS The reaction by HPIC,With the reaction yield for index,using the orthogonal experiment method,The reaction temperature(A),reaction time(B) and of catalyst(C) three factors,Each level of three experiment selection,The factors for horizontal L9(34) to arrange experiments,and finally determined the best reaction conditions.RESULTS The yied on the reaction is ABC,Temperature l70,the reaction time of 3 hours,10% of the amount of catalyst is the synthesis of 2-hydroxy-4-phenylbutanoic acid,reaction steps in the optimization of high-temperature reaction condtions.CONCLUSION Optimum conditions is A2B3C1,Namely,reaction temperature,reaction in 170℃ for 3 hours,catalyst for 10%.