James J. Li, Haixia Wang, J. Tino
Jun 1, 2007
Citations
10
Influential Citations
63
Citations
Quality indicators
Journal
Bioorganic & medicinal chemistry letters
Abstract
A novel series of 2-hydroxy-N-arylbenzenesulfonamides were identified to be ATP-citrate lyase (ACL) inhibitors with compound 9 displaying potent in vitro activity (IC(50)=0.13 microM). Chronic oral dosing of compound 9 in high-fat fed mice lowered plasma cholesterol, triglyceride, and glucose, as well as inhibited weight gain.