Z. Brzozowski
Jul 1, 1995
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0
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Journal
Acta poloniae pharmaceutica
Abstract
The 4-chloro-2-mercapto-5-methyl-N-[5-R1-amino-S-triazol-3-yl] benzenesulphonamides (I-III; R1 = H, Ph or 3-MeOPh) were converted into S-substituted derivatives IV-XIV as potential anti-HIV-1 and/or anticancer agents. Preliminary screening data of compounds [IV-V, VII-XI] and [XIV] indicate that some of them exhibit weak anticancer activity [IV and XI] and moderate anti-HIV-1 activity [IV]. Some structure-activity relationships are also discussed.