S. Hirpara, K. Parikh, B. C. Merja
May 1, 2003
Citations
0
Influential Citations
9
Citations
Journal
ChemInform
Abstract
Thiosemicarbazide 1 has been prepared by the reaction of 2-methoxy-5-methyl aniline, ammonia and carbon disulphide with ethanol (95%) and sodium chloroacetate, followed by addition of hydrazine hydrate, which on cyclisation with different aromatic carboxylic acids and substituted azlactones in pyridine furnish the corresponding 2-aryl-5-(2'-methoxy-5'-methylphenyl amino)-1,3,4-thiadiazoles 2a-o and 2-phenyl- 4-arylidene-1-(2'-methoxy-5'-methylphenyl thiourido)-5-oxo-imidazolines 3a-o. All the compounds have been characterised by elemental analyses, IR, 'H NMR and Mass spectral data. All the compounds have been evaluated in vitro for their antimicrobial activity against several microbes and antitubercular activity against Mycobacterium tuberculosis H 3 7 Rv and anticancer activity. Two compounds are found to be active in anticancer assay.