M. Maitre, L. Ciesielski, P. Mandel
Sep 1, 1974
Citations
0
Influential Citations
35
Citations
Journal
Biochemical pharmacology
Abstract
Abstract An increase in the level of γ-aminobutyric acid (GABA) in brain was observed after 2-methyl 2-ethyl caproic acid (MEC) and 2-2-dimethyl valeric acid (DMV) treatment, which protects sensitive mice against audiogenic seizures. Enzymatic studies have shown that MEC and DMV inhibit competitively GABA-transaminase with respect to GABA. MEC and DMV are α-substituted fatty acids of the same type as n -dipropyl acetic, a structural analogue of GABA.