Y. Yasaka, M. Tanaka, Takashi Matsumoto
Feb 1, 1990
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Influential Citations
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Journal
Analytical Sciences
Abstract
The use of 2-(phthalimino)ethyl trifluoromethanesulfonate in the preparation of carboxylic acid 2-(phthalimino)ethyl ester derivatives for specrophotometric detection in high performance liquid chromatography is described. The reagent is prepared in 60% yield by the reaction of N -hydroxyethylphthalimide with trifluoromethanesulfonic anhydride in the presence of pyridine in dichloromethane and is stable at least for 1 year in a refrigerator. Reactions of carboxylate potassium salts (10^−5 M) with a 10-fold equivalent excess amount of the reagent in acetonitrile at room temperature proceed to completion within 10 min in the presence of 18-crown-6 as a catalyst. The derivatization procedure with this reagent has been successfully applied to the determination of some carboxylic acids in mouse brain.