R. Friesen, C. Brideau, Chi-chung Chan
Oct 6, 1998
Citations
1
Influential Citations
106
Citations
Quality indicators
Journal
Bioorganic & medicinal chemistry letters
Abstract
A series of novel 2-pyridinyl-3-(4-methylsulfonyl)phenylpyridines has been synthesized and evaluated with respect to their ability to inhibit the isozymes of cyclooxygenase, COX-1, and COX-2. Optimum COX-2 activity is observed by introduction of a substituent at C5 of the central pyridine. 5- Chloro-3-(4-methylsulfonyl)phenyl-2-(2-methyl-5-pyridinyl)pyridine 33 was identified as the optimum compound in this series.