Y. Shimohigashi, H. Kodama, M. Waki
Oct 1, 1989
Citations
0
Influential Citations
3
Citations
Journal
Chemistry Letters
Abstract
Treatment of five tripeptide amides Boc-Phe-Leu-NHCH(R)CO-NH2 (R: side chain of Gly, Leu, Phe, Asp(OBzl), or Arg(Tos)) with [bis(trifluoroacetoxy)iodo]benzene and subsequent coupling with Boc-Phe-Leu-OH afforded the dimeric peptides cross-linked with 2-substituted gem-diamines; (Boc-Phe-Leu-)2·(-NHCH(R)NH-). gem-Asp(OBzl)-cross-linked dimer was further converted into enkephalin dimer, which was conjugated to Sepharose 4B gel for receptor affinity purification.