B. Goel, T. Ram, R. Tyagi
Mar 1, 1999
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0
Influential Citations
71
Citations
Quality indicators
Journal
European Journal of Medicinal Chemistry
Abstract
New anthranilic acid derivatives, 2-substituted-3-(4-bromo-2-carboxyphenyl)-5-methyl-4-thiazolidinone, were synthesized and evaluated for their anti-inflammatory activity against carrageenan-induced oedema in albino rats. The most active member of the series, 3-(4-bromo-2-carboxyphenyl)-2-(2-fluorophenyl)-5-methyl-4-thiazolidinone 6 was compared with phenylbutazone for its relative anti-inflammatory potency and ulcerogenic liability. ED50, cardiovascular and central nervous system effects of 6 were also studied.