F. Csende, J. Jekő,, Andrea Porkoláb
Nov 10, 2011
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Molbank
Abstract
Abstract: A simple solvent-free synthesis of 3-[1-(4-methylphenyl)-3-oxo-1,3,4,5,6,7-hexahydro-2 H -isoindol-2-yl]propanoic acid 3 was achieved by fusion of cis -2-[(4-methylphenyl)carbonyl]cyclohexanecarboxylic acid 1 with 3-aminopropanoic acid 2 . The structure of this new compound was confirmed by elemental analysis, IR, EI-MS, 1 H-NMR and 13 C-NMR spectral data. Keywords: isoindolone; 4-oxocarboxylic acid; -aminoacid 2,3-Dihydro-1 H -isoindolin-1-one (phthalimidine) as an important hetero ring system is core unit in various naturally occurring alkaloids or synthetic compounds. Several isoindolone derivatives have a range of biological activities including anti-inflammatory (indoprofen) [1], antiarrhytmic (ubisindine) [2,3], nootropic [4], anxiolytic and sedative (pazinaclone and pagoclone) [5,6] or diuretic and antihypertensive activity (chlorthalidone) [7]. Other derivatives have potent 5-HT 1A and 5-HT 2c receptor antagonist [8,9], antispasmodic [10], antinociceptive (JM-1232) [11] and hypnotic activity [12] while