Zou Jun
2007
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Journal
Fine and Specialty Chemicals
Abstract
3,3-Diethoxyethylcyanide was an important precursor for synthesis of vitamin B1,cytosine and its derivatives.In this paper several methods including acylamide dehydration,metal cyanide replacement,etherification and isoxazole method for synthesis of 3,3-diethoxyethylcyanide were reviewed.The method based on isoxazole using 1,1,3,3-tetraethoxypropane as raw material was a suitable route comparatively for commercial production of the title compound.