T. Meyer, R. R. Scheline
1972
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Influential Citations
11
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Quality indicators
Journal
Xenobiotica; the fate of foreign compounds in biological systems
Abstract
1. The metabolism of 3,4,5-trimethoxycinnamic acid and some related compounds in the rat has been investigated.2. The metabolic reactions observed were hydrogenation of the double bond, O-demethylation, p-dehydroxylation, dehydrogenation and O-methylation. In addition, the urinary metabolites were partly excreted as glucuronide and/or sulphate conjugates.3. Experiments with antibiotic-treated and germ-free rats showed that O-demethylation in the tissues occurred only at one of the meta-positions. Further O-demethylation and p-dehydroxylation to give the ultimate metabolite, 3,5-dihydroxyphenylpropionic acid, were dependent upon the activities of the intestinal micro-organisms.4. Interconversion of cinnamic and phenylpropionic acids has been demonstrated. Hydrogenation was mainly carried out by the intestinal microorganisms whereas dehydrogenation occurred only in the tissues.5. O-Methylation of 3,4,5-trihydroxyphenylpropionic acid occurred at both the para- and meta-positions. In the latter case further O...